TyG index, an insulin resistance marker, as mediator of BMI on prostate cancer death
Obesity has consistently been shown to be associated with a higher risk of prostate cancer (PCa) death. Insulin resistance is a hypothesized biological mechanism in this association; however, data in support of this hypothesis is limited. We investigated mediation of …
Metabolically (un)healthy obesity and risk of obesity-related cancers
Little is known about obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk. We investigated body mass index jointly and in interaction with metabolic health status in relation to obesity-related cancer …
The inverse association of body mass index with lung cancer
Body mass index (BMI) has been consistently, inversely associated with lung cancer risk. In our study of 778,828 individuals, we investigated if the association is explained by metabolic aberrations, residual confounding and within-person variability in smoking, and compared against other …
Metabolic factors and the risk of small intestine cancers
Little is known about the etiology of small intestine cancer. We investigated the association between BMI, mean arterial pressure, and plasma total cholesterol, triglycerides and glucose and risk of small intestine cancer in 807,485 men and women in Me-Can. During …
BMI and weight changes and risk of obesity-related cancers
Obesity is a major global health challenge, and an established risk factor for several cancers. Adult weight gain has been associated with increased cancer risk, but studies on timing and duration of weight gain have been relatively scarce. Within the …
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